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cm4 sensor chip  (Biacore)

 
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    Structured Review

    Biacore cm4 sensor chip
    (A) Trp emission fluorescence assays. The upper graph displays compounds with affinities below 100 µM, while the lower graph shows those with affinities above 100 µM. (B) Surface plasmon resonance experiments. Binding of the tested compounds at 100 µM over <t>CM4-immobilized</t> NCS-1. Each compound is indicated with a different color code. (C) The binding affinities of the best FDA-selected compounds. Dissociation constants (K d + SD) are indicated. Only compounds with a K d below 100 µM are shown. In parenthesis, the FDA code given for each compound is shown.
    Cm4 Sensor Chip, supplied by Biacore, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/cm4 sensor chip/product/Biacore
    Average 90 stars, based on 1 article reviews
    cm4 sensor chip - by Bioz Stars, 2026-04
    90/100 stars

    Images

    1) Product Images from "FDA drug repurposing uncovers modulators of dopamine D 2 receptor localization via disruption of the NCS-1 interaction"

    Article Title: FDA drug repurposing uncovers modulators of dopamine D 2 receptor localization via disruption of the NCS-1 interaction

    Journal: bioRxiv

    doi: 10.1101/2025.05.29.656787

    (A) Trp emission fluorescence assays. The upper graph displays compounds with affinities below 100 µM, while the lower graph shows those with affinities above 100 µM. (B) Surface plasmon resonance experiments. Binding of the tested compounds at 100 µM over CM4-immobilized NCS-1. Each compound is indicated with a different color code. (C) The binding affinities of the best FDA-selected compounds. Dissociation constants (K d + SD) are indicated. Only compounds with a K d below 100 µM are shown. In parenthesis, the FDA code given for each compound is shown.
    Figure Legend Snippet: (A) Trp emission fluorescence assays. The upper graph displays compounds with affinities below 100 µM, while the lower graph shows those with affinities above 100 µM. (B) Surface plasmon resonance experiments. Binding of the tested compounds at 100 µM over CM4-immobilized NCS-1. Each compound is indicated with a different color code. (C) The binding affinities of the best FDA-selected compounds. Dissociation constants (K d + SD) are indicated. Only compounds with a K d below 100 µM are shown. In parenthesis, the FDA code given for each compound is shown.

    Techniques Used: Fluorescence, SPR Assay, Binding Assay



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    Image Search Results


    (A) Trp emission fluorescence assays. The upper graph displays compounds with affinities below 100 µM, while the lower graph shows those with affinities above 100 µM. (B) Surface plasmon resonance experiments. Binding of the tested compounds at 100 µM over CM4-immobilized NCS-1. Each compound is indicated with a different color code. (C) The binding affinities of the best FDA-selected compounds. Dissociation constants (K d + SD) are indicated. Only compounds with a K d below 100 µM are shown. In parenthesis, the FDA code given for each compound is shown.

    Journal: bioRxiv

    Article Title: FDA drug repurposing uncovers modulators of dopamine D 2 receptor localization via disruption of the NCS-1 interaction

    doi: 10.1101/2025.05.29.656787

    Figure Lengend Snippet: (A) Trp emission fluorescence assays. The upper graph displays compounds with affinities below 100 µM, while the lower graph shows those with affinities above 100 µM. (B) Surface plasmon resonance experiments. Binding of the tested compounds at 100 µM over CM4-immobilized NCS-1. Each compound is indicated with a different color code. (C) The binding affinities of the best FDA-selected compounds. Dissociation constants (K d + SD) are indicated. Only compounds with a K d below 100 µM are shown. In parenthesis, the FDA code given for each compound is shown.

    Article Snippet: NCS-1 was immobilized on a CM4 sensor chip (Biacore, GE) following a standard amine coupling method.

    Techniques: Fluorescence, SPR Assay, Binding Assay